SimpleFold

Training compute

2×10²¹ FLOP

Parameters

3B

Published

Sep 23, 2025

SimpleFold is an AI model developed by Apple (United States), first published in September 2025. It works in the biology domain, on tasks such as protein folding prediction.

Training it took an estimated 2×10²¹ FLOP of compute (estimation method: reported,operation counting). The model has 3,000,000,000 parameters. It was trained on roughly 2.2B datapoints.

Access: Open weights (unrestricted). Its weights are openly available. Epoch AI rates the confidence of this record as confident.

Full record

Organization: Apple
Country of organization: United States
Domain: Biology
Task: Protein folding prediction
Training compute: 2×10²¹ FLOP
Compute estimation method: Reported, Operation counting
Parameters: 3,000,000,000
Dataset size: 2.2B
Model accessibility: Open weights (unrestricted)
Open weights: Yes
Epoch confidence: Confident