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Nucleotide Transformer

Training compute
8.1×10²¹ FLOP
Parameters
2.5B
Published
Jan 15, 2023

Nucleotide Transformer is an AI model developed by NVIDIA, Technical University of Munich and InstaDeep (United States, Germany and United Kingdom), first published in January 2023. It works in the biology domain, on tasks such as protein or nucleotide language model (plm/nlm) and nucleotide generation.

Training it took an estimated 8.1×10²¹ FLOP of compute (estimation method: operation counting,hardware). The model has 2,500,000,000 parameters. It was trained on roughly 300B datapoints. Training ran on 128 NVIDIA A100 for about 672 hours. The compute alone is estimated at $51K in 2023 dollars.

Access: Open weights (non-commercial). Its weights are openly available. The reference paper has 22 citations. Epoch AI rates the confidence of this record as likely.

Full record
Organization
NVIDIA, Technical University of Munich, InstaDeep
Country of organization
United States, Germany, United Kingdom
Domain
Biology
Task
Protein or nucleotide language model (pLM/nLM), Nucleotide generation
Training compute
8.1×10²¹ FLOP
Compute estimation method
Operation counting, Hardware
Parameters
2,500,000,000
Dataset size
300B
Training hardware
NVIDIA A100
Chips used
128
Training time
672 h
Chip-hours
86K
Training power draw
102.2 kW
Training cost (2023 USD)
$51K
Numerical format
FP32
Model accessibility
Open weights (non-commercial)
Open weights
Yes
Citations
22
Epoch confidence
Likely
SourceEpoch AI, 'AI Models'. Published online at epoch.ai. Retrieved 2026-07-29 from https://epoch.ai/data/ai-models. Licensed under CC BY 4.0.
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